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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE4C All Species: 28.79
Human Site: S126 Identified Species: 79.17
UniProt: Q08493 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q08493 NP_000914.2 712 79902 S126 S F L Y R S D S D Y E L S P K
Chimpanzee Pan troglodytes XP_001138439 809 91104 S197 S F L Y R S D S D Y D L S P K
Rhesus Macaque Macaca mulatta XP_001091815 725 82653 S125 S F L Y R S D S D Y D L S P K
Dog Lupus familis XP_852383 903 99971 S303 S F L Y R S D S D Y E L S P K
Cat Felis silvestris
Mouse Mus musculus Q3UEI1 686 76072 S128 S F L Y R S D S D H E P S P K
Rat Rattus norvegicus P14270 803 90534 S192 S F L Y R S D S D Y D L S P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695374 745 84839 S117 D L S P K S M S R N S S I A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W4S9 983 107322 S351 S F L Y R S D S D F E M S P K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22000 674 75370 S113 L T P S L S S S V H A R R E S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62.9 63.8 68.4 N.A. 70.9 63.5 N.A. N.A. N.A. N.A. 65.7 N.A. 41.9 N.A. 46.3 N.A.
Protein Similarity: 100 73.5 75.1 71.5 N.A. 77.9 73.7 N.A. N.A. N.A. N.A. 76.9 N.A. 53.5 N.A. 61.5 N.A.
P-Site Identity: 100 93.3 93.3 100 N.A. 86.6 93.3 N.A. N.A. N.A. N.A. 13.3 N.A. 86.6 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. N.A. N.A. 20 N.A. 100 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 12 0 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 0 0 0 78 0 78 0 34 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 45 0 0 12 0 % E
% Phe: 0 78 0 0 0 0 0 0 0 12 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % I
% Lys: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 78 % K
% Leu: 12 12 78 0 12 0 0 0 0 0 0 56 0 0 0 % L
% Met: 0 0 0 0 0 0 12 0 0 0 0 12 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % N
% Pro: 0 0 12 12 0 0 0 0 0 0 0 12 0 78 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 78 0 0 0 12 0 0 12 12 0 0 % R
% Ser: 78 0 12 12 0 100 12 100 0 0 12 12 78 0 23 % S
% Thr: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 78 0 0 0 0 0 56 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _